学术讲座【Vibrational Spectroscopic Imaging of Living Systems: Emerging Platform for Biology and Medicine】

时间：2015年5月7日（周四）15：00-16：00

地点：仓山校区光电学院科研楼四层学术报告厅

主办：光电与信息工程学院

主讲：Professor Ji-Xin Cheng

专家简介：Ji-Xin Cheng was born in Jixi, Anhui Province, P. R. China in 1971. He attended University of Science and Technology of China (USTC) from 1989 to 1994. From 1994 to 1998, he carried out his PhD study on bond-selective chemistry under the supervision of Qingshi Zhu at USTC. As a graduate student, he worked as a research assistant at Universite Paris-sud (France) on vibrational spectroscopy and the Hong Kong University of Science and Technology (HKUST) on quantum dynamics theory. After postdoctoral training on ultrafast spectroscopy in Yijing Yan’s group at HKUST, he joined Sunney Xie’s group at Harvard University as a postdoc, where he and others developed CARS microscopy that allows high-speed vibrational imaging of cells and tissues. Cheng joined Purdue University in 2003 as Assistant Professor in Weldon School of Biomedical Engineering and Department of Chemistry, promoted to Associate Professor in 2009 and Full Professor in 2013. He was appointed as Scientific Director of Label-free Imaging at Purdue’s Discovery Park in 2014. Professor Cheng’s research aims to transform molecular spectroscopy from an in vitro analytical tool to an in vivo imaging platform for biological and medical applications. His pioneering work includes CARS imaging of myelin sheath in its nature state, multimodal nonlinear optical microscopy, chemical imaging of deep tissue through acoustic detection of harmonic vibration, transient absorption microscopy of nanomaterials, and lock-in free stimulated Raman spectroscopic imaging. He is authored in over 170 peer-reviewed articles that have been cited more than 10,000 times, with an h-index of 50 (Google Scholar). He organized of 23 national/ international symposia, delivered over 170 invited talks, and served as co-editor of the first book on Coherent Raman Scattering Microscopy, published by CRC Press in 2012. His is a co-inventor of CARS microscope which is now available through Olympus and Leica. In 2013 He co-founded Vibronix Inc which has the mission of saving lives through vibrational imaging technology. He is the Purdue site director of NSF-funded I/UCRC Center for Biophotonics Sensors and Systems. Professor Cheng’s achievements have been recently recognized by Craver Award from Coblentz Society (2015), Chang-Jiang Scholar from Chinese Minister of Education (2015), Fellow of American Institute of Medicine and Biological Engineering (2014), Purdue University Faculty Scholar (2012-17), College of Engineering Early Career Research Award (2011), Research Excellence Award from Purdue Center for Cancer Research (2011), Outstanding Young Scientist Award from Chinese National Academy of Sciences (2009).

报告摘要：Current medical imaging modalities rely on differences in tissue properties rather than on chemical-content changes deep inside the body. Consequently, a biopsy is routinely needed for ultimate diagnosis of a malignancy. Thus, we need noninvasive imaging technologies that can be used in vivo and can determine in real time the chemical content of deep-tissue. Vibrational spectroscopy has been a powerful tool for quantitative analysis of molecules in gas phase or solutions and has been deployed for label-free analysis of excised biological tissues. Yet, applying vibrational spectroscopy to non-invasive in vivo imaging, from single live cells to the human body, is still difficult. I will present our persistent efforts in developing in vivo spectroscopic imaging platforms that have been enabling groundbreaking biological discoveries and paradigm-shifting diagnosis strategies. Specifically, I will present coherent Raman scattering microscopy for real-time spectroscopic imaging of living cells and vibration-based photoacoustic endoscopy/tomography for bond-selective imaging of deep tissues.